TP53 and DHEA This note was inspired by a very well-written, easy-to-read, but very long and complicated dissertation on how DHEA prevents cancer, entitled “DETECTION OF A NOVEL, PRIMATE-SPECIFIC ‘KILL SWITCH’ TUMOR SUPPRESSION MECHANISM THAT MAY FUNDAMENTALLY CONTROL CANCER RISK IN HUMANS: AN UNEXPECTED TWIST IN THE BASIC BIOLOGY OF TP53”, by Jonathan W Nyce, In: Endocr Relat Cancer. 2018 Nov; 25(11): R497–R517., Published online 2018 Jun 25. Doi: 10.1530/ERC-18-0241, PMCID: PMC6106910, PMID: 29941676 , at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106910/    DNA DAMAGE AND MALIGNANT TRANSFORMATION Our cells are constantly exposed to a variety of cellular stressors and are prone to DNA damage, which can…

Hi All, I just found an Article in JAMA (the Journal of the American Medical Association), dated June 21, 2021, by WK Silverstein and D. Grady, entitled “Overuse of Levothyroxine in Patients With Subclinical Hypothyroidism: Time to “Leve”-Out-Thyroxine“.The abstract (the summary) of this article reads as follows: “Recent clinical trials and a meta-analysis demonstrate no symptomatic benefit from treatment with levothyroxine among nonpregnant adults with subclinical hypothyroidism ……. Contemporary evidence-based clinical practice guidelines strongly advise against levothyroxine (ELTROXIN or SYTHROID) supplementation for subclinical hypothyroidism …. (and) …. older guidelines from professional societies generally do not recommend treatment for subclinical hypothyroidism.”…

Here is one more anecdotal story. In February of 2020, my wife went to London for a conference, returning on the 5th of March.On the return trip she had a mild sore throat, which she reported to the border officer at the airport: she was advised that since she was feeling fine, there was no need for a covid-19 test. On the news two days later we heard that Sophie Trudeau had returned from London with a covid-19 infection, the night before my wife’s flight. We did not develop any respiratory symptoms and we decided not to worry about it, but five days later I…

As I understand it, “functional medicine” includes:1] EDUCATED PATIENTS: The high school curriculum includes hormonal, metabolic and microbiome health as a formal subject, so that all understand health maintainance.2] HEALTH CARE PRACTITIONER: The healthcare professional is an MD, trained in the application of the principles of standard medicine and in the art of metabolic and hormonal maintenance. *3] FIRST ASSESSMENT: Preferably, the first assessment should be at age 15; it can be done earlier if puberty begins before age 11 or if the child is obese, anorexic, depressed or subject to PTSD for any reason.The patient’s physical, psychological, metabolic and…