STRESS: WHAT DOES IT DO TO YOU, AND WHAT YOU CAN DO
What stress does to you
Stress causes low T3 syndrome (a.k.a.intracellular hypothyroidism, functional hypothyroidism, “nonthyroidal illness” and confused, with “chronic fatigue syndrome”).
Intracellular hypothyroidism (IH) is a shortage of thyroid hormone 3 (T3) inside all cells of the body, which decimates the efficiency of every individual cell.
IH produces a variable suite of “low thyroid” symptoms, depending on which organs in the body are most sensitive to “T3 starvation”. However, the commonest complaints are feeling cold, fatigue in the afternoon, anxiety, “fuzzy thinking” and weight gain.
Intracellular hypothyroidism Is the root cause of most “autoimmune” illness.
Most illnesses, from depression to chronic fatigue syndrome, from high blood pressure to heart attacks, from obesity to diabetes, from cancers to neurodegenerative conditions, etc. etc. are more common among chronically stressed, poor and disadvantaged people than they are among those who are well-to-do and relatively stress-free: the link between socioeconomic stress and chronic illness is a “no-brainer”.
However, the best example of illness brought on by stress is PTSD.
PTSD, the plague of military veterans, can result from any high-grade stress.
It can begin at any age and is often seen in abused children.
It may lead to virtually all types of noncommunicable illness, including autoimmune diseases and cancers, but its most frequent symptoms are those of “low thyroid”.
How stress causes low T3 syndrome
Stress raises blood cortisol, which blocks production of T3, the active thyroid hormone.
All your cells need T3 and can’t function efficiently if they don’t have enough.
So to understand how stress produces illness, you first have to know how T3, your body’s “accelerator”, is made.
The thyroid gland makes Thyroxine (“T4”), a chemical with 4 iodine atoms attached.
T4 is not actually a hormone: it is raw material for Triiodothyronine (“T3”), the “accelerator hormone”, which increases the efficiency of all our cells.
Deiodinase enzymes, the iodine removers
We have 3 completely different enzymes*, called “de-iodinases” (D1, D2 and D3), each of which can remove one iodine atom from T4.
D1: To make T3, all our cells (except in the pituitary gland) remove a special iodine atom from T4 with deiodinase 1 (D1).
D2: The pituitary cells do the same, but they use their own enzyme, D2.
D3: The body also has a “shutdown enzyme”, D3, which the pituitary does not have.
D3 removes the wrong iodine atom, converting T4 into a twisted T3, “reverse T3”.
D3 also takes an “I” atom off of any T3 it finds, producing T2 (see the graphic, below).
Reverse T3 and T2 don’t work: they are “garbage”. **
* An enzyme is a protein molecule in cells which works as a biological catalyst. Enzymes speed up chemical reactions in the body, but do not get used up in the process, so they can be used over and over again.
** a very recent article describes the actions of T2 made from normal, T3 and separately, “reverse T2”, made from reverse T3. This is not of clinical interest at this point in time, but when it has been completely investigated, it may prove to be important.
If you are interested, click HERE.
THIS IS WHAT DEIODINASES DO
This was copied from
“Cardiomyocyte-specific inactivation of thyroid hormone
in pathologic ventricular hypertrophy: an adaptative response or part of the problem?”,
by Christine J. Pol, Alice Muller, and Warner S. Simonides, in “Heart Fail Review”, Nov 24, 2008).
Cortisol and stress
Stress causes low T3 by increasing production of cortisol, the “stress hormone” (perhaps cortisol should be called “the shutdown hormone”).
Cortisol blocks D1, so inside the cells, T3 production stops.
Cortisol also turns on D3, so inside the cells, T4 is converted into reverse T3.
D3 also takes an iodine atom from any T3 in the cells, making T2, which is also inactive.
Therefore the effect of cortisol is to almost completely remove T3 from your cells.
The cells of the pituitary gland are unaffected
The pituitary uses D2 . It doesn’t have D1 or D3.
So it keeps on making T3 for its own use and it doesn’t make reverse T3.
It doesn’t notice that anything has gone wrong, so it keeps on making TSH
(thyroid stimulating hormone), according to how much T4 is available to it.
What’s the diagnosis?
I call this situation, where stress causes low T3 in the cells, “Intracellular Hypothyroidism” and thyroid-savvy practitioners call it “Functional Hypothyroidism”.
But traditional doctors have given it various names, like
“Low T3 syndrome”,
“Euthyroid Sick Syndrome”,
Also, some writers don’t link stress with low T3 and chronic fatigue: they talk about
Chronic Fatigue Syndrome (CFS), CFS/ME, “Long Covid” etc.
All these conditions cause the symptoms of “true” Hypothyroidism.
These illnesses cause the same symptoms as hypothyroidism:
In both true hypothyroidism (when the thyroid gland doesn’t produce enough T4) and intracellular hypothyroidism, the cells have the same problem: they don’t have enough T3 to work efficiently.
What’s the connection to aging?
Aging doesn’t cause intracellular hypothyroidism by itself.
However as you get older, your hormone production (including your T4 production) goes down, so your cells may not be working properly in the first place.
In old age, the cells are already “dragging along”, with less internal T3 than they had when you were young. So it’s that much easier for low-grade stress to push them into severe “T3 starvation”, producing the hypothyroidism symptoms mentioned above.
Thus the effects of stress, physical or psychological, tend to be worse in older folks.
What’s the connection to other diseases?
Every serious, life-threatening disease, and every life-changing condition, causes stress.
Starvation, obesity, depression, social or economic pressures, abuse, PTSD for whatever reason, severe injury, burns, major surgery with complications etc. all cause stress.
The stress raises cortisol production.
Cortisol blocks T3 and intracellular hypothyroidism starts.
So low intracellular T3 is a feature of all admissions to Hospital ICUs.
The doctors don’t know what’s happening
The other thing is that your MD won’t notice that anything has gone wrong either.
The only way to diagnose intracellular hypothyroidism is to test for T3 and rT3 and figure out the T3/rT3 ratio.
So tests for TSH, T4, T3 and reverse T3 should be done in every serious illness.
But T3 and rT3 aren’t tested: doctors are told that TSH is the only valid test for thyroid function and the system threatens to “discipline” them if they do “unnecessary tests”.
Treatment for Intracellular Hypothyroidism:
There is no way to block cortisol production, but you can supply your cells with the T3 that they are not making, by taking a daily pill until the stressful period is over.
This works very well and the stress-related symptoms go away quickly.
However if no life-threatening disease is involved, simply eliminating the stress might reduce cortisol production, allow T3 generation in the cells and relieve the symptoms.
This is why meditation and relaxation help some people with CFS, Fibromyalgia and Long Covid.
What you can do
If you are simply weak and tired from stress, or if you have a serious disease plus fatigue, what you can do is:
(1) Read and learn about intracellular hypothyroidism via this website.
(2) “De-stress”: listen to music, dance, meditate, take a nap, walk (or sit) in the woods.
I’m stress-free–how’re you doin’ ?
(3) Consult with a functional medicine physician for analysis of your hormone balance, including tests for TSH, T4, T3 and reverse T3 and for treatment with T3 if you have IH.
(3) Follow that physician’s instructions re. correction of your T3 and other hormones.
A search, on stress relief.
Of the many websites which purport to solve the problem of “stress”, most peddle patent remedies of one sort or another.
However I have found one very well-designed website which gives well-considered advice in a tasteful and pleasant, non-capitalistic way.
Check the website below, for stress-relieving ideas:
go to https://wellnesscentral.info/physical-mental-health-resources/