More about DCM

This new (August, 2021), very well-written paper, entitled
Thyroid Hormones—An Underestimated Player in Dilated Cardiomyopathy?“,
comes very close the truth of T3’s influence on heart health and function.
The authors have managed to review all the important facts on the subject, up to and including a mention of reverse T3, without coming to the conclusion that full thyroid testing might disclose functional hypothyroidism and by so doing, permit the prescription of Triiodothyronine for cure of this almost universally fatal disease (many DCM subjects, even those treated by heart transplant, die).

J Clin Med. 2021 Aug; 10(16): 3618. Published online 2021 Aug 16. doi: 10.3390/jcm10163618PMCID: PMC8397026PMID: 34441915, Karolina Zawadzka,1Radosław Dziedzic,1Andrzej Surdacki,2 and Bernadeta Chyrchel2,*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397026/

ABSTRACT:
Dilated cardiomyopathy (DCM) is the most prevalent cardiomyopathy, typified by left ventricular dilation and systolic dysfunction. Many patients with DCM have altered thyroid status, especially lower levels of free triiodothyronine (T3) and elevated levels of thyroid-stimulating hormone. Moreover, growing evidence indicates that even subtle changes in thyroid status (especially low T3) are linked with a worse long-term prognosis and a higher risk of mortality. Notably, recent discoveries have shown that not only local myocardial thyroid hormones (THs) bioavailability could be diminished due to impaired expression of the activating deiodinase, but virtually all genes involved in TH biosynthesis are also expressed in the myocardium of DCM patients. Importantly, some studies have suggested beneficial effects of TH therapy in patients suffering from DCM. Our aim was to discuss new insights into the association between TH status and prognosis in DCM, abnormal expression of genes involved in the myocardial synthesis of TH in DCM, and the potential for TH use in the future treatment of DCM.

MESSAGE:
(1) A “Thyroid profile”, including TSH, T4, T3 and rT3 (with T3/rT3 calculation) should be part of the “workup” for all major diseases and conditions.
(2) When the T-profile shows functional hypothyroidism, treatment with slow-release T3, to correct the functional hypothyroidism, should be given in addition to whatever specific therapy is recommended for the condition (excepting that if T4 is recommended, T3 should be given instead).

Published by Dr. Gervais Harry

I am a Toronto-trained Urologist. I practiced in downtown Toronto, from 1977 to 1997, when I went to Saudi Arabia as chief of Urology at the Armed Forces (teaching) hospital in Tabuk. Returning to Toronto in Y2000, I switched to family practice. In 2007, began to prescribe Hormone Restoration Therapy and in 2012, I became a member of the American Academy of Antiaging Medicine [A4M]. I successfully wrote the A4M's written examination in December, 2013 and In May, 2016 I passed the oral examination, for accreditation as a BHRT consultant. In 2014 I began BHRT practice in Collingwood, Ontario and in January, 2017, joined the Stone Tree Naturopathic Clinic. Now I am 82 and have retired, but it seems wasteful to jettison my learning and experience: the medical establishment knows nothing of BHRT / Functonal medicine and I feel obliged to offer my knowledge in the interest of those who are willing to think outside the box. MY QUALIFICATIONS: MB, BS, (from UWI), 1964. LMCC 1969. FRCSC (Urology), 1974. ECFMG 1984. Florida license 1998 [inactive], ABAARM Certification [A4M], 2016. I am a Member of CSAMM [the Canadian Society for Aging and Metabolic Medicine], the OMA&CMA, SUSO, CUA, RCP&S/C. PRACTICE TO DATE: Consultation in Functional Medicine, including assessment of Chronic Fatigue Syndrome, Fibromyalgia, Andropause, Menopause, Teenage and Postpartum Depression/Panic Attacks, Thyroid Hormone malfunction, Infertility, Sexual Dysfunction and “the Undiagnosable”. ALL ARE WELCOME to read, comment or question!

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