MORE, ON BAT (BROWN FAT)

Posted byGervaisPosted inUncategorized

Notes on BAT distribution, BAT stimulation and weight loss

October 25, 2023 – By Dr. Gervais Harry

Here we go, to BAT, again!

BAT cells have many active mitochondria and WAT cells have hardly any. On the other hand, white fat cells swell, with a huge globule of fatty acids and oils, while BAT does not store fats.
A few WAT (white adipose tissue) progenitor (stem) cells can convert to “Beige adipocytes” in cold-weather conditions, or when stimulated by administration of Triiodothyronine (T3), but they are less efficient heat producers than the BAT is.

Graphic 1, White, brown and beige adipocytes (from Wikipedia).

A report from “Medscape”, written by Courtney Southwick, dated 10/17/23, advises us that that the sympathetic-nerve pathways that activate brown fat have been precisely mapped. She credits Prof. Preethi Srikanthan, MD, endocrinologist, and a group at UCLA and other sites, who dissected 8 human cadavers, tracing the sympathetic nerve branches which accompany the 3rd and 4th Cervical (neck) nerves, to the brown fat above and behind the clavicles.

Congratulations, to Shumpei Mori, et al.

The original article, entitled “Sympathetic Innovation of the Supraclavicular Brown Adipose Tissue: A Detailed Anatomical Study”, was Published on October 4, 2023, in “Plos One” (https://doi.org/10.1371/journal.pone.0290455), by Shumpei Mori, Ryan S. Beyer, Breno Bernardes de Souza, Julie M. Sorg, Donald B. Hoover, Harold S. Sacks, Michael C. Fishbein, Grace Chang, Warwick J. Peacock, Maie A. St. John, James Law, Micheal E. Symonds, Olujimi A. Ajijola, Kalyanam Shivkumar, and Preethi Srikanthan,

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Published by Gervais

I am a Toronto-trained Urologist. I practiced in downtown Toronto, from 1977 to 1997, when I went to Saudi Arabia as chief of Urology at the Armed Forces (teaching) hospital in Tabuk. Returning to Toronto in Y2000, I switched to family practice. In 2007, began to prescribe Hormone Restoration Therapy and in 2012, I became a member of the American Academy of Antiaging Medicine [A4M]. I successfully wrote the A4M's written examination in December, 2013 and In May, 2016 I passed the oral examination, for accreditation as a BHRT consultant. In 2014 I began BHRT practice in Collingwood, Ontario and in January, 2017, joined the Stone Tree Naturopathic Clinic. Now I am 85 and retired, but it seems wasteful to jettison my learning and experience: the medical establishment knows nothing of BHRT / Functonal medicine and I feel obliged to offer my knowledge in the interest of those who are willing to think outside the box. QUALIFICATIONS: MB, BS, (UWI), 1964. LMCC 1969. FRCSC (Urology), 1974. ECFMG 1984. Florida license [inactive], ABAARM 2016. Affiliations: CSAMM, OMA, CMA, SUSO, CUA, RCP&S/C. PRACTICE TO DATE: Consultation in Functional Medicine: Chronic Fatigue Syndrome, Fibromyalgia, Andropause, Menopause, Teenage and Postpartum Depression/Panic Attacks, Thyroid Hormone malfunction, Infertility, Sexual Dysfunction and “the Undiagnosable”. ALL ARE WELCOME to read, comment or question!