Alzheimer’s, new treatments

We continue to be bombarded with scientific articles, detailing new modifiers and new treatments for Alzheimer’s disease: most of these are ineffective, but some reports do contain a hint of a possible solution.

Encouraging news

The latest effort is entitled “ALZ-801 for 2 years sustained cognition in early Alzheimer’s: no safety issues seen in a 2 year long, Phase 2 trial of Alzheon’s oral therapy”, posted by Steve Bryson, PhD, in “Alzheimer’s news today”, on 22 September, 2023.

This report describes a Phase 2 clinical trial (NCT04693520), designed to evaluate the two-year safety and efficacy of daily ALZ-801 in 84 adults with early Alzheimer’s who had either one or two copies of APOE4 and who tested positive for amyloid and tau biomarkers in their cerebrospinal fluid (CSF, the liquid surrounding the brain and spinal cord).
The investigators achieved a reduction of serum beta-amyloid and tau by 4%, with slowing of shrinkage of the hippocampus (by 28%) and a significantly reduced rate of cognitive decline.

This is encouraging news for people with early Alzheimer’s disease. However from a metabolic medicine/hormonal balance point of view there is, as I said in my last post, an elephant in the room. That elephant is a fact of which we are all aware: Alzheimer’s disease develops over several decades and may be slowed (perhaps, stopped), but not reversed. Therefore, it makes better sense to concentrate on prevention, diagnosis-at-onset and really early treatment, rather than cure of an entrenched, progressive disease.

Alzheimer’s prevention

“Yes”, you say, “but how can you prevent Alzheimer’s, when you have no idea as to its cause?” – My answer is that there is a putative cause, since
(1) Alzheimer’s is due to degeneration of neurons and
(2) Our maintenance and repair systems, dependent as they are on hormonal balance, as well as adequate mineral and vitamin availability, begin to decline at age 26 as hormone production slows and vitamin/mineral deficiencies develop.

The continuous decline of hormone secretion beginning at age 26, and deficiency of essential mineral and vitamin intake, are easily observed and well known. We have good scientific reason to supplement our failing hormones, vitamins and minerals. If Alzheimer’s is actually due to deterioration of our maintenance systems as hormone production declines, essential dietary and hormone supplementation might reduce its incidence or at least, delay its onset.

Surveillance and supplementation

I therefore propose that we should proactively assess each individual’s hormone balance on an ongoing basis and supplement their hormones and their diet ad hoc, while monitoring the blood for tau and beta-amyloid. If this is done, we could observe whether hormone supplementation delays the onset of Alzheimer’s disease. Also, those who become tau and beta-amyloid positive would be available for studies of new treatments for Alzheimer’s, such as Dr. Bryson’s, at the onset of their disease.

I am a Toronto-trained Urologist. I practiced in downtown Toronto, from 1977 to 1997, when I went to Saudi Arabia as chief of Urology at the Armed Forces (teaching) hospital in Tabuk. Returning to Toronto in Y2000, I switched to family practice. In 2007, began to prescribe Hormone Restoration Therapy and in 2012, I became a member of the American Academy of Antiaging Medicine [A4M]. I successfully wrote the A4M's written examination in December, 2013 and In May, 2016 I passed the oral examination, for accreditation as a BHRT consultant. In 2014 I began BHRT practice in Collingwood, Ontario and in January, 2017, joined the Stone Tree Naturopathic Clinic. Now I am 82 and have retired, but it seems wasteful to jettison my learning and experience: the medical establishment knows nothing of BHRT / Functonal medicine and I feel obliged to offer my knowledge in the interest of those who are willing to think outside the box. MY QUALIFICATIONS: MB, BS, (from UWI), 1964. LMCC 1969. FRCSC (Urology), 1974. ECFMG 1984. Florida license 1998 [inactive], ABAARM Certification [A4M], 2016. I am a Member of CSAMM [the Canadian Society for Aging and Metabolic Medicine], the OMA&CMA, SUSO, CUA, RCP&S/C. PRACTICE TO DATE: Consultation in Functional Medicine, including assessment of Chronic Fatigue Syndrome, Fibromyalgia, Andropause, Menopause, Teenage and Postpartum Depression/Panic Attacks, Thyroid Hormone malfunction, Infertility, Sexual Dysfunction and “the Undiagnosable”. ALL ARE WELCOME to read, comment or question!

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